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I am interested in the general hypothesis that cellular signaling
systems exploit their intracellular spatial features such as
molecular crowding and protein localization to optimize their
functions. I am studying signal response characteristics of
the Alpha pathway by combining computer simulation and in vivo
measurement techniques including fluorescence correlation spectroscopy.
One of my long-term goals is development of integrative technology
for whole-cell scale modeling and simulation at the molecular
level. I am the creator of the E-Cell System, a multi-scale,
multi-algorithmic cellular simulation platform, and a core
founder of the E-Cell Project. I am continuing active involvement
in the project through development of the next version of the
E-Cell System (version 4) at MSI. I am a Human Frontier Science
Program Fellow.
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